Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury
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منابع مشابه
Proper Heat Shock Pretreatment Reduces Acute Liver Injury Induced by Carbon Tetrachloride and Accelerates Liver Repair in Mice
Whether proper heat shock preconditioning can reduce liver injury and accelerate liver repair after acute liver injury is worth study. So mice received heat shock preconditioning at 40°C for 10 minutes (min), 20 min or 30 min and recovered at room temperature for 8 hours (h) under normal feeding conditions. Then acute liver injury was induced in the heat shock-pretreated mice and unheated contr...
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Background and Aim: Silymarin, obtained from Silybum marianum has hepatoprotective effects and antioxidant activity and has been used in the treatment of liver diseases. Because of its poor aqueous solubility and low bioavailability its use has been limited. The aim of this study was to prepare a new and inexpensive formulation of silymarin using simple dissolution methods and compare its hepat...
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Quercetin is a typical flavonoid with diverse biological effects, attributable to its free radical scavenging activity. Bioavailability of quercetin aglycone and its glycosides is an important factor for its antioxidant activity in vivo. A severe limitation exists and is imputable to very poor absorption of quercetin when administered orally. To overcome this limitation, development of a value ...
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Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4). Materials and Methods: The acute liver injury model was produced by CCl4 at 10 ml/kg body weight in 24-...
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AIM To study the effect of WeiJia on chronic liver injury using carbon tetrachloride (CCl(4)) induced liver injury animal model. METHODS Wistar rats weighing 180-220g were randomly divided into three groups: normal control group (Group A), CCl(4) induced liver injury control group (Group B) and CCl(4) induction with WeiJia treatment group (Group C). Each group consisted of 14 rats. Liver dama...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2014
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.39.339